DHEA Cream Fights Cortisol

To maintain optimal health and well-being, humans need adequate levels of dehydroepiandrosterone, known as DHEA. DHEA is the most abundant naturally occurring pro-hormone in the human body. DHEA levels gradually increase from birth to about age 25, when we are in our “reproductive prime” as humans. After age twenty-five, DHEA levels begin to decrease by about 2% per year. As an important prohormone, or building block for hormones, DHEA plays a crucial role in many body functions. So as levels of DHEA decline, people notice they have trouble sleeping, lack energy or focus during the day, gain weight more easily, lose muscle tone and sharpness of mind. Low levels of DHEA are associated with “diseases of aging”, such as greater risk of cancer, cardiovascular disease, depression and insomnia, to name but a few.

Cortisol increases gradually over the human lifespan while DHEA decreases Cortisol is known as the stress hormone.

Cortisol is produced in response to stressful situations. It is the “fight or flight” hormone released to protect the body with an inflammatory response. The problem with this inflammatory response is that, over time too much cortisol on a chronic basis has many detrimental effects. Since we gradually make less and less DHEA after age 25. On the otherhand, we gradually make more and more cortisol as we get older. Humans are at their healthiest, feel best and are at lowest risk of disease – cardiovascular disease, diabetes, depression and cancer when the DHEA to cortisol is at a ratio of ten to one (10:1) according to Dr. John R. Woodward, M.D.

Everything, from driving in rush-hour traffic to dealing with an upset friend or co-worker, can cause stress in our lives, producing more cortisol. Elevated cortisol levels over time can lead to impaired immune response, energy drain, feeling bloated, low energy, weight gain and feeling washed out. Cortisol can also adversely affect cardiovascular health, blood glucose levels and bone strength. High cortisol levels can lead to the development of Metabolic Syndrome, which has been shown to lead to obesity, high blood pressure, and higher cholesterol and triglyceride levels. DHEA counterbalances the negative effects of cortisol.

DHEA and Cortisol

DHEA is the only thing in the body that counterbalances the negative effects of cortisol. There is a great article about “Adrenal Exhaustion” by Dr. Christiane Northrup, MD, describing the all common usual life scenario of high cortisol with low DHEA so common adults. Given the gradual declines in DHEA and the gradual increases in cortisol as we age, using DHEA cream daily make sense.

DHEA – A DHEA Cream Rather Than A Pill

Dehydroepiandrosterone (DHEA) was first identified by Dr. Adolf Butenandt, a German biochemist, in 1931. Dr. Butenandt was awarded the Nobel Prize for chemistry in 1939.[1] DHEA is primarily produced in the adrenal glands, gonads and skin. DHEA is a naturally occurring pro-hormone or hormone precursor. In 1944, the sulfated form of DHEA was isolated (DHEA-S).

Clinical research revealed that humans make increasing amounts of DHEA from birth to about age 25. DHEA is the most abundant hormone precursor. Men and women produce maximum levels during the years of reproductive prime; but then, the amount of DHEA produced steadily declines at a rate of about 2% per year from about age 25-30 until death.[2]  Medical research performed in the 1960’s and 1970’s demonstrated improvements in physical and psychological well-being with regard to bone strength, improved sleep, as well as cardiovascular benefits.

Medical research studies published in the 1980’s and 1990’s continued to confirm that DHEA supplementation was beneficial for numerous biological and cognitive health outcomes. [3] In 1994 Dr. Samuel Yen, a world-renown endocrinologist at the University of California at San Diego and subject matter expert, concluded that DHEA may help people age more gracefully, sleep better at night, and have a greater sense of well-being. The highly respected hormone expert reported this at the New York Academy of Sciences in June 1995. Dr. Yen’s conducted research which demonstrated that DHEA replacement activates the immune system, increases well-being, boosts energy levels, improves mood, and allows a greater ability to cope with stressful events. [4]

In the 1990’s through 2008, Dr. Fernand Labrie, the principal investigator at University of Toronto Medical School in Canada, published important studies demonstrating that DHEA, and it’s use as a cream, yields significant health benefits. In these studies, Dr. Labrie’s preferred method of use was DHEA applied as a specially formulated cream.

Dr. Fernand Labrie’s study results demonstrate that when DHEA is taken orally as a pill, spray or troche, most DHEA is eliminated by the first-pass effect of the liver, thereby primarily increasing only DHEA-sulfate (DHEA-S) levels in the bloodstream – not free DHEA, which is what serves as a base for the sex hormones. DHEA-S is not readily converted into free DHEA as was found by Dr. Fabien Hammer et al in his study titled “No Evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: In vivo and in vitro studies” (www.ncbi.nlm.nih.gov/pubmed/15755854). [5] Thus, DHEA pills yield little to no noticeable benefits the user can feel.  However, a properly made 5% (50 mg/cc) DHEA cream does provide the user noticeable benefits. Medical research findings support this as do the experience of thousands of Twist 25 users.

Research shows that it is in the skin (dermis), the largest organ of the human body, where much DHEA is metabolized, especially after menopause or andropause. In fact, excellent research done by Dr. Fernand Labrie et al (See “Adrenal androgens and intracrinology” www.ncbi.nlm.nih.gov/pubmed/15635498 ) determined that for postmenopausal women, more than 88 % of hormones are metabolized in the skin, and for men more than 50%. [6][7]

Twist 25 DHEA cream provides bioidentical DHEA via a specially designed, compounded cream base made with coconut oil, so DHEA is absorbed in the dermis yielding noticeable benefits within just a few weeks.

Twist 25 DHEA cream is absorbed and processed in the skin, not through the gut and liver.

One full pump press of Twist 25 cream contains 25 mg DHEA. The cream is applied daily on thin hairless skin. Twist 25 cream is best applied daily on the inner arm between wrist and elbow; and rubbed in with the arm in a circular motion on the side or abdomen until it is absorbed. This takes about 10 seconds and leaves no odor or residue.

Twist 25 cream was developed by Dr. John R. Woodward, a board-certified medical doctor who specializes in bioidentical hormone replacement therapy. Twist 25 DHEA cream has been used and tested for over 30 years. It is safe and effective. The favorable user outcomes and lack of adverse results speak for themselves.


[1] www.nobelprize.org/nobel_prizes/chemistry/laureates/1939/butenandt-bio.html
[2] Guber HA, Farag AF, Lo J, Sharp J. Evaluation of Endocrine Function.  Henry’s Clinical Diagnosis and Management by Laboratory Methods.  21st edition Philadelphia, PA: W.B. Saunders Company; 2006: Chapter 24
[3] Fernand Labrie, Alain Belanger, Rene Berube, et al. University of Toronto Medical School. The Journal of Steroid Biochemistry and Molecular Biology Vol 103(2), Issue 2, Feb 2007, Pgs 178-188
[4] WorldHealth.net “About DHEA” by Bill Freeman Nov 10 2003 https://www.worldhealth.net/news/about_dhea/
[5] Fabian Hammer, Sandra Subtil, Philipp Lux, Christiane Maser-Gluth, Paul M. Stewart, Bruno Allolio and Wiebke Arlt. No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and in Vitro Studies. Journal of Clinical Endocrinology and Metabolism Vol. 90, No. 6 3600-3605
[6] Labrie, Fernand, Belanger, Alain, Belanger, Patrick, Berube, Rene, Martel C, Cusan L, Gomez, J, et al “Metabolism of DHEA in postmenopausal women following percutaneous administration”. ScienceDirect Pubmed. Journal of Steroid Biochemistry and Molecular Biology 103 (2007) 178-188.  http://www.ncbi.nlm.nih.gov/pubmed/17084625
[7] Labrie F, Belanger A, Labrie C, Candas B, Cusan L, Gomez JL. “Bioavailability and metabolism of oral and percutaneous dehydroepiandrosterone in postmenopausal women”. Journal of Steroid Biochemistry and Molecular Biology. Jun 8 2007 PubMed https://www.ncbi.nlm.nih.gov/pubmed/17627814
Apply DHEA Cream to your skin twice a day

Improving Menopause Symptoms with DHEA

If you’re starting to go through menopause, you’re probably tired of the symptoms most women go through: the hot flashes that keep you up at night, diminished skin tone, changes in mood, increased anxiety, forgetfulness and lack of concentration. While these symptoms vary in intensity from woman to woman, most women experience one or more of these symptoms during menopause between the ages of 40 to 60, and many seem to be under the impression that there isn’t much they can do about it, outside of controversial Hormone Replacement Therapy.

Fortunately, the unpleasant symptoms of menopause can be alleviated with the help of Twist 25 DHEA cream because DHEA is a natural pro-hormone, or base for hormones. According to information from the University of Maryland Medical Center, DHEA supplements have been shown to raise hormone levels in pre- and post-menopausal women. Medical studies such as the one performed at the University of Pisa have even shown that DHEA can be as effective as Hormone Replacement Therapy in helping to reduce menopausal symptoms by supporting healthier hormone levels. With all of the negative press Hormone Replacement Therapy has been getting recently, many women are opting for bioidentical DHEA cream to keep their symptoms in check.

As mentioned above, the reason DHEA cream helps women to maintain healthier hormone levels is because DHEA is a base building block for about 50 hormones, including estrogen, estrone, estradiol and testosterone. As we age, our bodies produce less and less DHEA, leaving us producing about half as much DHEA by age 50 as when we were in our 20s. Interesting research done by Dr. Fernand Labrie showed that after menopause, women actually make more than 80 percent of their hormones in the skin, the dermis, the largest organ of the body. Without this important pro-hormone, DHEA, people simply feel washed out, have low energy, sleep poorly, gain weight more easily, have little interest in sex and basically lack enthusiasm and drive. The reason? Our health and happiness are largely controlled by our hormones.

Using a bioidentical DHEA cream called Twist 25 can help to fight other symptoms of aging, too. Lower than normal levels of DHEA have been associated with osteoporosis, heart disease, memory loss, depression and greater risks for cancer. Higher levels of DHEA are associated with greater bone strength, reduced risk of cardiovascular disease, dementia, improving mood and reduced risk of cancer.

It is very important to use DHEA as a properly made bioidentical DHEA cream you can trust rather than a pill. No other DHEA cream on the market has been tested with the same rigor as Twist 25 DHEA cream. We’ve been researching and perfecting Twist 25 DHEA Cream for more than two decades. Apply a pump or two of Twist 25 cream to your skin each day and start feeling better. The little things we do each day make a big difference over time. Twist 25 DHEA cream is the perfect advantage to stave off the unpleasant signs of menopause. It’s what the body makes naturally applied where the body uses it naturally anyway.

DHEA Cream applied to your skin can help you feel younger

An Easy Way to Feel Happier and Avoid Antidepressants

If you haven’t been feeling like yourself lately, you’re probably looking for any solution to help you feel happier. Maybe the things that have always worked — time with family or friends, reading a book you love, etc. — just aren’t helping anymore, and you’re not sure what to do about it. For some people, this is when they turn to antidepressants to feel better.

Unfortunately, antidepressants are not always the best answer when it comes to mild or moderate depression. Many people who don’t have severe symptoms often would prefer to handle their depression without taking antidepressant drugs. For others, antidepressants are just not effective or leave them in a haze, or a constant roller-coaster. There are other people who just may have the blues and don’t feel like antidepressants are an option at all. In many cases, low dehydroepiandrosterone, or DHEA, level may be the reason for the low vitality and lack of energy; so taking a properly made bioidentical DHEA supplement cream may help to bring up a person’s mood and vitality, so they can once again find the happiness and joy of life that often seems just out of reach.

DHEA is a pro-hormone that is naturally secreted by the adrenal glands, gonads and skin. DHEA is a precursor or base building block for the production of hormones, like testosterone and estrogen, which can affect your mood. It’s an unfortunate fact, but after people reach their mid-twenties, DHEA levels begin to diminish at a rate of about 2% per year; so by age 35 most people are make 20% less than when they were “in their prime” and by age 50, middle age, DHEA levels are down to about 50 percent of the optimal levels.

Bringing up your DHEA levels can help you feel happier, more energetic and less moody throughout the day, with a greater sense of focus, and more well-being and drive. Researchers have found that DHEA supplementation helps to reduce symptoms of depression for people with “the blues” who are feeling down, especially when these symptoms of depression worsen during middle age.

In addition to making you feel happier, DHEA can help you be more productive and generally healthier too: supporting cardiovascular health, immune response and reducing risks of cancer. This is because DHEA is the most abundant pro-hormone in the body. People who add DHEA to their daily routine have been found to have more energy and get more done. With your hormones in balance, your mind is less foggy. You can think more clearly, making daily routines easier and more enjoyable.

For optimal results, opt for a bioidentical DHEA cream that is absorbed and processed in the skin, where it occurs naturally anyway. Twist 25 DHEA cream provides what the body makes naturally, bioidentical DHEA, where the body uses it, the skin. Instead of taking pills every day, simply apply a skin cream to DHEA the right way, and be happier and healthier as a result. Make Twist 25 DHEA cream part of your daily routine.

At Health2Go, we’re proud to offer Twist 25 DHEA cream to help support your body’s optimal functioning. No other DHEA cream has been tested and improved with the same rigor as Twist 25. Just rub in a a couple of squirts of Twist 25 cream twice a day to regain youthful health and happiness.

Health 2 Go when you want to feel better apply DHEA Cream twice a day

Feel Better While Fighting Fibromyalgia

Receiving a diagnosis of fibromyalgia can be devastating. You feel tired all the time, your muscles hurt, and you struggle to sleep at night. These symptoms can seriously interfere with your daily activities, and, if you’re like most people with fibromyalgia, you are looking for relief. However, this condition can be a challenge for doctors to treat. One substance that many people have turned to for help fighting fibromyalgia is dehydroepiandrosterone, or DHEA.

Your body creates DHEA naturally in the adrenal glands, gonads and the skin. Your body also makes cortisol, and this stress hormone increases your appetite while toning down the immune system’s inflamatory responses. As we get older, we gradually make more and more cortisol; and less and less DHEA.

Ideally cortisol is only released into the system occasionally, rather than on a chronic basis. But in todays busy world, many people deal with ongoing stress every day, for years at a time. If cortisol levels are too high for too long, they may have undesireable side effects including loss of bone density, muscle wasting, thinning of skin, fluid retention, weight gain, increased vulnerability to bacteria, viruses, and cancer. When cortisol is up, your DHEA levels are down. The two hormones have an inverse relationship in the body. DHEA counterbalances the harmful effects of cortisol. One of the things that DHEA helps the body do is support immune response by increasing both the number of and activity of natural killer cells that destroy foreign cells and thereby help us to resist diseases.

Two of the most difficult symptoms of fibromyalgia are lack of energy and difficulty sleeping. Some people with fibromyalgia have trouble going to sleep, while others can manage to fall asleep but are unable to remain in a deep sleep throughout the night. Some people may have trouble concentrating because of a condition that is called “fibro fog.”

As an important pro-hormone, DHEA has been proven to allow deeper REM (rapid eye movement) sleep. This is the sleep in which you dream – the deep restful sleep that allows you to wake up feeling alive and alert and ready to go. DHEA also helps people regain focus and a sense of well-being.

If you are wary of taking supplements by mouth, you are in luck because DHEA works best as a bioidentical cream, applied on the skin — the dermis, where your body makes and uses it naturally. Twist 25 DHEA cream is bioidentical DHEA with water, coconut oil, vitamin E and Coenzyme Q-10. No other DHEA supplement has been tested like Twist 25 cream. Just apply a pump or two of this cream to your skin each day, and your body will use it to help you sleep better at night, improve your ability to concentrate and generally feel better.

Counterbalance the negative effects of cortisol and make your own hormones. Look your best feel your best with Twist 25.